Case Report: Blood single-cell analysis of a IVB high-grade serous ovarian cancer patient presenting a favorable prognosis
This integrative molecular and phenotypic profiling of blood-derived components identified potentially distinct molecular signatures, such as overexpression of IL12, ANGPT1 downregulation and HIF1A downregulation, in the literature described as linked to the patient's beneficial prognosis. These findings suggest that advanced liquid biopsy techniques may provide complementary insights into prognostic biomarkers and therapeutic targets in HGSOC.
Authors
- Dagmara Klasa-Mazurkiewicz (ORCID: https://orcid.org/0000-0003-0122-9504)
- Sylwia Łapińska‐Szumczyk (ORCID: https://orcid.org/0000-0002-1422-5767)
- Paulina Jackowiak (ORCID: https://orcid.org/0000-0003-4067-6788)
- Krzysztof Pastuszak (ORCID: https://orcid.org/0000-0002-5562-0114)
- Anna Samelak-Czajka (ORCID: https://orcid.org/0000-0002-0167-8265)
- Anna Maria Supernat (ORCID: https://orcid.org/0000-0002-3113-0540)
- Natalia Bednarz‐Knoll (ORCID: https://orcid.org/0000-0001-9506-942X)
- Michał Sieczczyński
- Anna Joanna Zaczek (ORCID: https://orcid.org/0000-0003-1482-6068)
- Małgorzata Wolańska (ORCID: https://orcid.org/0000-0002-6859-367X)
Institutions
- Gdańsk University of Technology (PL)
- University of Gdańsk (PL)
- Institute of Bioorganic Chemistry, Polish Academy of Sciences (PL)
- Gdańsk Medical University (PL)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-11-24
- DOI
- https://doi.org/10.3389/fonc.2025.1697863
- Primary Topic
- Ovarian cancer diagnosis and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Agencja Badań Medycznych
- European Regional Development Fund