Circulating innate lymphoid cells and IL-18 as potential immune biomarkers in thymic tumors
These findings delineate a distinct systemic immune signature in TETs, characterized by IL-18 upregulation and altered ILC1 dynamics, with potential implications for immune regulation and autoimmunity. Circulating ILC profiling combined with IL-18 measurement may represent a promising approach for patient stratification, disease monitoring, and the development of novel immunomodulatory strategies in TETs.
Authors
- Giovannella Palmieri (ORCID: https://orcid.org/0000-0003-0139-6038)
- Daniela Terracciano (ORCID: https://orcid.org/0000-0003-4296-429X)
- Marianna Tortora (ORCID: https://orcid.org/0000-0002-9853-9594)
- Giuseppe Ercolano (ORCID: https://orcid.org/0000-0001-6026-2588)
- Daniela Claudia Maresca
- Mario Giuliano (ORCID: https://orcid.org/0000-0003-0835-3153)
- Alberto Servetto (ORCID: https://orcid.org/0000-0003-3624-224X)
- Evelina La Civita (ORCID: https://orcid.org/0000-0003-0543-9031)
- Benedetta Romano
- Erica Pietroluongo (ORCID: https://orcid.org/0000-0003-2370-2139)
- Angela Ianaro
- Fabio Somma
- Maria Rosaria Saponaro
Institutions
- Regione Campania (IT)
- Federico II University Hospital (IT)
- University of Naples Federico II (IT)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-24
- DOI
- https://doi.org/10.3389/fimmu.2025.1705648
- Primary Topic
- Myasthenia Gravis and Thymoma
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Associazione Italiana per la Ricerca sul Cancro
- European Network for Rare Adult Solid Cancers