Impact of vaginal microbiota on the clinical efficacy and long-term recurrence of ketoconazole suppositories in treating severe vulvovaginal candidiasis: a secondary analysis of a multicentre randomised trial

The vaginal microbiota, particularly the dominant bacteria, may influence treatment efficacy and recurrence rates. In the treatment of severe vulvovaginal candidiasis, ketoconazole suppositories are not inferior to miconazole nitrate vaginal capsules in clinical efficacy and have a lower long-term recurrence rate.