Enterohemorrhagic Escherichia coli O157 outer membrane vesicles administered by oral gavage cause renal tubular injury and acute kidney failure in mice
Orally administered EHEC O157 OMVs translocated from the gastrointestinal tract to the kidneys, where they caused tubular epithelial injury followed by acute kidney failure. Combined with their cytotoxicity toward HRGECs and HK-2 cells and detection in patient sera, these findings indicate that EHEC O157 OMVs contribute to the pathogenesis of EHEC-HUS.
Authors
- Alena Vlková (ORCID: https://orcid.org/0000-0002-8353-8038)
- Jakub Zieg (ORCID: https://orcid.org/0000-0001-6077-9536)
- Daniel Krsek
- Martina Bielaszewska (ORCID: https://orcid.org/0000-0002-1226-7066)
- Jaromír Háček (ORCID: https://orcid.org/0000-0002-7020-6229)
- Alžběta Spálenková (ORCID: https://orcid.org/0000-0002-4704-0283)
- Tereza Tesařová (ORCID: https://orcid.org/0000-0002-1035-7375)
- Tomáš Sychra
- Radka Václavíková
- Emin Gayibov
- Lukáš Kolařík
Institutions
- Charles University (CZ)
- National Institute of Public Health (JP)
- University Hospital in Motol (CZ)
- National Institute of Public Health (LA)
- University Hospital Kralovske Vinohrady (CZ)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-11-24
- DOI
- https://doi.org/10.3389/fcimb.2025.1704731
- Primary Topic
- Escherichia coli research studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00