Preclinical Alzheimer's and vascular biomarkers alter brain aging in cognitively normal adults: a MRI-based study
Preclinical AD and vascular biomarkers significantly alter brain aging in cognitively normal individuals. These findings highlight the importance of biomarker stratification in brain age studies to avoid biased estimates. Entorhinal cortex and amygdala volumes may serve as sensitive early indicators of neurodegeneration, supporting their use in targeted interventions and personalized monitoring.
Authors
- Olatz Arbelaitz (ORCID: https://orcid.org/0000-0001-7371-2971)
- Ainara Estanga (ORCID: https://orcid.org/0000-0002-6616-314X)
- David Bello (ORCID: https://orcid.org/0000-0002-6887-1676)
- Pablo Martínez‐Lage
- Ibai Gurrutxaga (ORCID: https://orcid.org/0000-0003-1830-1058)
- Ubaldo Torres
Institutions
- University of the Basque Country (ES)
- Fundacion CITA Alzheimer (ES)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-11-24
- DOI
- https://doi.org/10.3389/fnagi.2025.1653074
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00