Hepatocyte RAP1A Deletion Impairs Lipid Catabolism and Worsens Steatosis via Autophagy Activation
RAP1A is a critical regulator of hepatic lipid metabolism, safeguarding against diet-induced steatosis and metabolic dysfunction. Its absence leads to lipid buildup and impaired metabolic homeostasis via disruptions in lipid accumulation, mitochondrial function, autophagy, and ERK signaling.
Authors
- Zhonggui Luo
- Yinxu Fu (ORCID: https://orcid.org/0009-0004-0810-6974)
- Qiongya Zhao (ORCID: https://orcid.org/0000-0001-9616-4787)
- Kaiqiang Yang
- Liqin Jin (ORCID: https://orcid.org/0000-0002-1351-1948)
- Jianxin Lyu (ORCID: https://orcid.org/0000-0003-2343-1666)
- Xi Lin (ORCID: https://orcid.org/0000-0003-3911-9677)
- Keyi Li (ORCID: https://orcid.org/0009-0004-2712-2208)
- Fang Yu (ORCID: https://orcid.org/0009-0004-2747-3972)
- Xiujuan Wei (ORCID: https://orcid.org/0000-0003-0576-1258)
- Ting Fu (ORCID: https://orcid.org/0000-0003-3518-6469)
Institutions
- Wenzhou Medical University (CN)
- Zhejiang Provincial People's Hospital (CN)
- Hangzhou Medical College (CN)
Publication Details
- Journal
- Diabetes & Metabolism Journal
- Published
- 2025-11-24
- DOI
- https://doi.org/10.4093/dmj.2025.0388
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China