Impact of MEK inhibition on T-cell infiltration and function after radiotherapy in KRAS-mutant lung cancer
Our findings suggest that MEKi activates the cGAS-STING-TANK-binding kinase 1-nuclear factor kappa B-CXCL10 axis post-radiotherapy in KRAS-mutant lung cancer, increasing T-cell infiltration and function, activating anti-tumor immunity, and inhibiting tumor growth. These results indicate the potential for clinical translation.
Authors
- Peng Yan (ORCID: https://orcid.org/0000-0002-8854-0217)
- Mingyan Zhang (ORCID: https://orcid.org/0000-0002-4413-7784)
- Jianji Pan (ORCID: https://orcid.org/0000-0002-3211-7874)
- Meili Sun (ORCID: https://orcid.org/0000-0002-4914-6508)
- Yufeng Wang (ORCID: https://orcid.org/0000-0002-4576-1984)
- Ning Liu (ORCID: https://orcid.org/0000-0003-1009-1201)
- Yawen Zheng (ORCID: https://orcid.org/0000-0002-9630-8194)
- Mengmeng Zhao (ORCID: https://orcid.org/0000-0002-4973-5353)
- Chen Su (ORCID: https://orcid.org/0000-0002-3556-9542)
Institutions
- Jinan Central Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-24
- DOI
- https://doi.org/10.3389/fimmu.2025.1663502
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- China Postdoctoral Science Foundation