Periodontitis biomarkers through thermal desorption-gas chromatography-mass spectrometry analysis
We developed a novel method for analyzing salivary volatile metabolites using TD-GC-MS, demonstrating potential for periodontitis diagnosis. Cyclohexanone is identified as a potential biomarker for periodontitis, and the caprolactam degradation pathway may play a significant role in future studies on oral microbiota dysbiosis in periodontitis patients.
Authors
- Xiaoli Zhang (ORCID: https://orcid.org/0000-0003-3702-3700)
- Yajuan Lei
- Liang Qin (ORCID: https://orcid.org/0000-0003-4257-8647)
- Xiaodong Li (ORCID: https://orcid.org/0000-0003-0346-1526)
- Yanlin Zhang (ORCID: https://orcid.org/0000-0002-8722-8635)
- Yizhou Liu (ORCID: https://orcid.org/0000-0002-1396-922X)
- Chao Yuan (ORCID: https://orcid.org/0000-0003-2311-1435)
- Shaoyong Xu (ORCID: https://orcid.org/0000-0002-8260-2456)
Institutions
- Peking University (CN)
- National Clinical Research (US)
- Shimadzu (China) (CN)
Publication Details
- Journal
- Frontiers in Dental Medicine
- Published
- 2025-11-24
- DOI
- https://doi.org/10.3389/fdmed.2025.1684773
- Citations
- 1
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 1.47