Defining the optimal Ki67 cutoff values for survival prediction in neoadjuvant chemotherapy-treated patients with breast cancer
A Ki67 cutoff of 20% serves as a reliable predictor of DFS and OS in patients with breast cancer receiving NAC. The developed nomogram models, incorporating Ki67 and other clinical parameters, provide an accurate and clinically valuable tool for individualized prognostic assessment.
Authors
- Yu Zong (ORCID: https://orcid.org/0000-0002-8546-8969)
- Yuxuan Song (ORCID: https://orcid.org/0000-0002-5302-7835)
- Jiawen Bu (ORCID: https://orcid.org/0000-0002-7168-3721)
- Xudong Zhu (ORCID: https://orcid.org/0000-0002-6657-6112)
- Ruibin Liu (ORCID: https://orcid.org/0000-0002-7507-9126)
- Yong Jiang (ORCID: https://orcid.org/0000-0002-8450-7786)
- Jiang Du (ORCID: https://orcid.org/0000-0003-2147-569X)
- Tong Fei Zhu (ORCID: https://orcid.org/0000-0002-2752-7924)
- Dan Zhang (ORCID: https://orcid.org/0000-0003-1295-4795)
- Junming Dai (ORCID: https://orcid.org/0000-0003-3733-9035)
- Xin Wang (ORCID: https://orcid.org/0000-0002-2937-0625)
- Chun Jiang (ORCID: https://orcid.org/0000-0003-4481-3604)
- Baifang Ding
- Zhuozheng Shi
Institutions
- University of Kentucky (US)
- Markey Cancer Center (US)
- Liaoning Provincial People's Hospital (CN)
- Jiangjin Central Hospital (CN)
- Liaoning Cancer Hospital & Institute (CN)
- China Medical University (CN)
Publication Details
- Journal
- Frontiers in Surgery
- Published
- 2025-11-24
- DOI
- https://doi.org/10.3389/fsurg.2025.1697963
- Primary Topic
- Breast Cancer Treatment Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- China Medical University
- Shengjing Hospital