Long-term multicomponent exercise enhances functional mobility in early-stage Parkinson’s disease: a 48-month retrospective cohort study
Long-term engagement in a multicomponent exercise program produces <i>sustained functional improvements exceeding measurement error</i> in mobility among individuals with early-stage PD, independent of changes in aerobic capacity or muscle mass. VO<sub>2</sub>peak consistently predicted functional outcomes, highlighting aerobic fitness as a key therapeutic target. These findings support the systematic integration of structured, multicomponent exercise into standard care protocols to preserve mobility and independence in PD.
Authors
- Marina Lívia Venturini Ferreira (ORCID: https://orcid.org/0000-0002-9869-6848)
- Miguel Soares Conceição (ORCID: https://orcid.org/0000-0002-9170-7890)
- Marcos Boaventura de Moura (ORCID: https://orcid.org/0000-0003-2342-2567)
- João Vitor Cerávolo Rostirola (ORCID: https://orcid.org/0000-0002-3010-8739)
- Edevaldo Donizetti de Campos
- Filipe Duo Speri (ORCID: https://orcid.org/0000-0002-7865-6195)
- Luiza Clertiani Vieira Alves (ORCID: https://orcid.org/0009-0007-3350-3586)
Institutions
- Universidade de São Paulo (BR)
- Universidade São Francisco (BR)
Publication Details
- Journal
- Frontiers in Physiology
- Published
- 2025-11-24
- DOI
- https://doi.org/10.3389/fphys.2025.1700510
- Citations
- 1
- Primary Topic
- Balance, Gait, and Falls Prevention
- Type
- article
- Field-Weighted Citation Impact
- 4.76