Bacteroides ovatus-derived N-methylserotonin inhibit colorectal cancer via the HTR1D-mediated cAMP-PKA-NF-κB signaling axis
B.o and its metabolite NMS possibly inhibit CRC progression by modulating the HTR1D-mediated cAMP/PKA/NF-κB signaling pathway, while improving gut microbiota structure, providing a novel therapeutic target for CRC prevention and treatment.
Authors
- Lizhou Jia (ORCID: https://orcid.org/0000-0003-0645-1868)
- Wenhao Qu
- Jiaqi Jia (ORCID: https://orcid.org/0000-0002-2501-3161)
- Jikai He
- Yan-Qiang Huang (ORCID: https://orcid.org/0000-0002-0867-0178)
- Keyu Fan (ORCID: https://orcid.org/0009-0008-9432-8387)
- Shuyu Zhang (ORCID: https://orcid.org/0000-0003-1419-3635)
- Wei Zhao (ORCID: https://orcid.org/0000-0001-8557-297X)
- Yan Niu (ORCID: https://orcid.org/0009-0008-5154-2607)
- Runze Lin (ORCID: https://orcid.org/0009-0001-0853-5945)
Institutions
- Peking University (CN)
- Soochow University (CN)
- Hetao College (CN)
- Peking University People's Hospital (CN)
- People's Hospital of Bishan District (CN)
- Affiliated Hospital of Youjiang Medical University for Nationalities (CN)
- Inner Mongolia Medical University (CN)
- University of Rochester (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-24
- DOI
- https://doi.org/10.3389/fimmu.2025.1696701
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00