PRMT1 drives oral squamous cell carcinoma progression by activating STAT3 and suppressing ferroptosis via GPX4
PRMT1 drives OSCC aggressiveness by methylating and activating STAT3. This axis promotes chemoresistance and oncogenic phenotypes primarily by suppressing ferroptosis through STAT3-mediated transcriptional upregulation of GPX4. Targeting PRMT1 represents a promising strategy to overcome chemoresistance and inhibit progression in OSCC.
Authors
- Connie R. Shi (ORCID: https://orcid.org/0000-0001-9166-1549)
- Bo Wei (ORCID: https://orcid.org/0000-0001-8033-5668)
- Huawei Liu (ORCID: https://orcid.org/0000-0003-4433-5075)
- Yingying Wu (ORCID: https://orcid.org/0000-0003-3837-0050)
- Peng Chen (ORCID: https://orcid.org/0000-0002-1277-0358)
- Bing Liu (ORCID: https://orcid.org/0000-0001-5302-0900)
Institutions
- Chinese PLA General Hospital (CN)
- Air Force General Hospital PLA (CN)
Publication Details
- Journal
- Cell & Bioscience
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1186/s13578-025-01506-7
- Primary Topic
- Cancer-related gene regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00