Cepharanthine may inhibit the proliferation of prostate cells by blocking the EGFR/PI3K/AKT signaling pathway: comprehensive network analysis, molecular docking, and experimental evaluation
This study confirmed for the first time the effectiveness of CEP in targeted regulation of prostatic hyperplasia. However, the <i>in vivo</i> efficacy needs to be verified in testosterone-induced animal models in the future.
Authors
- Jinze Li (ORCID: https://orcid.org/0000-0001-5187-8057)
- Yin Huang (ORCID: https://orcid.org/0000-0001-6913-4670)
- Yan Wang (ORCID: https://orcid.org/0000-0003-2563-255X)
- Jie Chen (ORCID: https://orcid.org/0000-0002-2852-3618)
- Jin Li (ORCID: https://orcid.org/0000-0002-1340-7761)
- Bo Chen (ORCID: https://orcid.org/0000-0001-5748-8551)
- Zeyu Chen (ORCID: https://orcid.org/0000-0001-8534-0829)
- Qiang Wei (ORCID: https://orcid.org/0000-0003-4531-1155)
- Dehong Cao (ORCID: https://orcid.org/0000-0002-6393-1625)
- Jingxing Bai
- Liangren Liu
- Qiang Dong
- Biao Ran
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Chengdu University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-11-24
- DOI
- https://doi.org/10.3389/fphar.2025.1654757
- Primary Topic
- Urinary Bladder and Prostate Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- West China Hospital, Sichuan University