Methamphetamine and neuroHIV suppress astrocytic potassium channel function in the medial prefrontal cortex via different mechanisms
Collectively, these findings demonstrate that Meth and neuroHIV inhibit astrocyte function, which could exacerbate mPFC neuronal dysfunction in MUD and/or neuroHIV. They also suggest that Meth- and neuroHIV-induced astrocytic K<sup>+</sup> channel function was mediated by TAAR1-and/or chemokine receptor-coupled signaling pathways.
Authors
- Lena Al‐Harthi (ORCID: https://orcid.org/0000-0003-3915-3904)
- João I. Mamede (ORCID: https://orcid.org/0000-0002-6048-1876)
- Lihua Chen (ORCID: https://orcid.org/0000-0003-2195-7330)
- Xiu‐Ti Hu (ORCID: https://orcid.org/0000-0002-4463-2216)
- Stefanie L. Cassoday
Institutions
- Rush University Medical Center (US)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-11-24
- DOI
- https://doi.org/10.3389/fphar.2025.1691165
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Institute on Drug Abuse