VPS35 D620N mutation impairs neurogenesis and promotes ferroptosis in Parkinson’s disease by using molecular docking, molecular dynamic simulation, and cellular model
This study highlights that the VPS35 D620N mutation may impair neurogenesis through ferroptosis mediated by dysregulation of the PI3K-Akt pathway, offering novel mechanistic insights into its role in PD pathogenesis.
Authors
- Hongxia Fu (ORCID: https://orcid.org/0000-0002-6893-8260)
- Leo Y. Luo (ORCID: https://orcid.org/0000-0002-3061-4287)
- Jie Li (ORCID: https://orcid.org/0000-0002-6912-3346)
- Zijie Qiu (ORCID: https://orcid.org/0000-0003-0728-1178)
- Xuliang Deng (ORCID: https://orcid.org/0000-0003-1838-6274)
- Xiaojun Cui (ORCID: https://orcid.org/0000-0001-6565-3086)
- Jiankai Zhang
- Yuan Fu (ORCID: https://orcid.org/0000-0002-5352-0961)
- Zixiong Qiu (ORCID: https://orcid.org/0009-0002-7554-2237)
- Mei Jiang
Institutions
- Guangdong Medical College (CN)
- Dongguan University of Technology (CN)
- Songshan Lake Materials Laboratory (CN)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-11-25
- DOI
- https://doi.org/10.3389/fnagi.2025.1692687
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Basic and Applied Basic Research Foundation of Guangdong Province