Outside Back Cover: Solvent Channels and Electric Fields Guide Proton Delivery to the Active Site of Heme Peroxidases (Angew. Chem. Int. Ed. 50/2025)
Local electric fields guide protons toward the heme through two distinct electrostatic funnels at the γ- and δ-edges in heme peroxidases. Water-mediated pathways enable proton exchange with key residues such as Arg38 and His42. These findings reveal that nature pre-organizes electrostatic funnels and solvent channels to provide multiple, well-defined routes for proton delivery, conserved across heme peroxidase enzymes. More in the Research Article (e202515743) by Reynier Suardíaz, Emma L. Raven, Adrian J. Mulholland, and co-workers.
Authors
- Emma Lloyd Raven (ORCID: https://orcid.org/0000-0002-1643-8694)
- Marc W. van der Kamp (ORCID: https://orcid.org/0000-0002-8060-3359)
- P.C.E. Moody (ORCID: https://orcid.org/0000-0003-1762-9238)
- Hanna Kwon (ORCID: https://orcid.org/0000-0001-6941-4808)
- Adrian John Mulholland (ORCID: https://orcid.org/0000-0003-1015-4567)
- Lola González‐Sánchez (ORCID: https://orcid.org/0000-0002-7800-5739)
- Reynier Suardíaz (ORCID: https://orcid.org/0000-0002-1035-9020)
- Shakir Ali Siddiqui (ORCID: https://orcid.org/0000-0002-3518-2823)
Institutions
- Universidad Complutense de Madrid (ES)
- University of Leicester (GB)
- Universidad de Salamanca (ES)
- University of Bristol (GB)
Publication Details
- Journal
- Angewandte Chemie International Edition
- Published
- 2025-11-23
- DOI
- https://doi.org/10.1002/anie.2025-m1711051200
- Primary Topic
- Porphyrin Metabolism and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00