Enoxaparin alleviates preeclampsia by enhancing trophoblast function via the NSUN2-mediated m5C methylation of PAX3 mRNA
Enoxaparin mitigated PE progression by upregulating NSUN2, which enhanced PAX3 expression via site-specific m<sup>5</sup>C methylation, thereby improving trophoblast function. The NSUN2/m<sup>5</sup>C/PAX3 axis represents a novel mechanistic insight and potential therapeutic target for PE.
Authors
- De Zeng (ORCID: https://orcid.org/0000-0002-9141-5505)
- Xuan Zhong (ORCID: https://orcid.org/0009-0000-1258-4363)
Institutions
- Shantou University (CN)
- Second Affiliated Hospital of Shantou University Medical College (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1186/s40001-025-03548-6
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00