Galunisertib attenuates pulmonary fibrosis with silicosis in mouse via TGF-β/TRAF6/Beclin1 signaling pathway
These findings indicate that Galunisertib can modulate autophagy in pulmonary tissues of silicotic mice and fibroblast cells by suppressing the TGF-β/TRAF6/Beclin1 signaling pathway. On the other hand, Galunisertib regulates autophagy and inhibits the activation, proliferation and migration of Silica-stimulated fibroblasts, alleviating fibrosis in silicosis mice. Altogether, Galunisertib may be a potential candidate drug for preventing pulmonary fibrosis.
Authors
- Rou Li (ORCID: https://orcid.org/0000-0001-7266-6213)
- Huimin Kang
- Tinghua Yan
- Shi Chen (ORCID: https://orcid.org/0000-0002-2961-436X)
- Ting Liu (ORCID: https://orcid.org/0000-0003-1816-5551)
- Guo Chen (ORCID: https://orcid.org/0000-0003-3688-7654)
- Aoxiang Hu
Institutions
- Central South University (CN)
- Hunan Normal University (CN)
- Second Xiangya Hospital of Central South University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-11-25
- DOI
- https://doi.org/10.3389/fphar.2025.1702511
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00