COVID-19 pandemic and enrollment of critically Ill children in randomized clinical trials
The COVID-19 pandemic is associated with lower enrollment rates in RCTs enrolling critically ill children. Increased parental refusal post-pandemic is confounded by reduced research staff availability. Further investigation is needed to assess the role of science denialism and identify strategies to enhance enrollment in RCTs of critically ill children.
Authors
- David Panisello‐Manterola
- Madhuradhar Chegondi (ORCID: https://orcid.org/0000-0002-1375-6988)
- Sarah Kandil (ORCID: https://orcid.org/0000-0002-2618-2119)
- Christie Glau (ORCID: https://orcid.org/0000-0003-1583-4609)
- Hilary Schreiber
- E. Vincent S. Faustino (ORCID: https://orcid.org/0000-0001-6155-2691)
- Jill M. Cholette
- Michele Kong (ORCID: https://orcid.org/0000-0001-6596-3965)
- Christine Allen (ORCID: https://orcid.org/0000-0002-4916-3965)
- Matthew G. Pinto
Institutions
- Children's Hospital of Philadelphia (US)
- Lake Erie College of Osteopathic Medicine (US)
- Medical College of Wisconsin (US)
- University of Alabama at Birmingham (US)
- Yale University (US)
- Maria Fareri Children's Hospital (US)
- Golisano Children's Hospital (US)
- Children's Hospital of Illinois (US)
- University of Oklahoma Health Sciences Center (US)
Publication Details
- Journal
- Frontiers in Pediatrics
- Published
- 2025-11-25
- DOI
- https://doi.org/10.3389/fped.2025.1704390
- Primary Topic
- Ethics and Legal Issues in Pediatric Healthcare
- Type
- article
- Field-Weighted Citation Impact
- 0.00