Individualised treatment effects of enhanced early mobilisation in mechanically ventilated patients: a secondary analysis of the TEAM trial
Using baseline characteristics, a machine learning model identified patients with estimated benefit or harm with enhanced EM. Future testing of a personalised approach to mobilisation in the ICU is warranted.
Authors
- Belinda J. Gabbe (ORCID: https://orcid.org/0000-0001-7096-7688)
- Michael Bailey (ORCID: https://orcid.org/0000-0002-5551-1401)
- Rinaldo Bellomo (ORCID: https://orcid.org/0000-0002-1650-8939)
- Stefan Josef Schaller (ORCID: https://orcid.org/0000-0002-6683-9584)
- Matthew W. Semler (ORCID: https://orcid.org/0000-0002-7664-8263)
- Sally Hurford (ORCID: https://orcid.org/0000-0003-2027-3754)
- Jeffrey Presneill (ORCID: https://orcid.org/0000-0001-7177-7667)
- Doug William Gould (ORCID: https://orcid.org/0000-0003-4148-3312)
- Heidi Buhr (ORCID: https://orcid.org/0000-0001-8452-2241)
- Theodore John Iwashyna (ORCID: https://orcid.org/0000-0002-4226-9310)
- Claire J. Tipping (ORCID: https://orcid.org/0000-0003-2543-1467)
- Meg Harrold (ORCID: https://orcid.org/0000-0002-2978-9098)
- Paul Jeffrey Young (ORCID: https://orcid.org/0000-0002-3428-3083)
- Carol Lynette Hodgson (ORCID: https://orcid.org/0000-0001-9002-2075)
- Tessa Broadley (ORCID: https://orcid.org/0000-0002-5555-0777)
- Ary Serpa Neto (ORCID: https://orcid.org/0000-0003-1520-9387)
- Pratik Sinha (ORCID: https://orcid.org/0000-0003-3751-9079)
- Alisa M. Higgins (ORCID: https://orcid.org/0000-0001-8295-7559)
- Alexandra B. Spicer (ORCID: https://orcid.org/0000-0001-9195-2143)
- Emma J. Graham Linck
- Janani Sivasuthan
- Matthew M. Churpek (ORCID: https://orcid.org/0000-0002-4030-5250)
- Steven Webb (ORCID: https://orcid.org/0000-0001-9134-9045)
- Alistair D. Nichol (ORCID: https://orcid.org/0000-0002-4771-5615)
- Kathy Brickell (ORCID: https://orcid.org/0000-0002-4935-7639)
Institutions
- St John of God Subiaco Hospital (AU)
- The Royal Melbourne Hospital (AU)
- University of Wisconsin–Madison (US)
- Johns Hopkins University (US)
- The University of Melbourne (AU)
- Vanderbilt University (US)
- Washington University in St. Louis (US)
- Curtin University (AU)
- Royal Prince Alfred Hospital (AU)
- Royal Perth Hospital (AU)
- Wellington Hospital (NZ)
- The Alfred Hospital (AU)
- Humboldt-Universität zu Berlin (DE)
- The George Institute for Global Health (AU)
- St. Vincent's University Hospital (IE)
- Monash Health (AU)
- Medical Research Institute of New Zealand (NZ)
- St John of God Hospital (AU)
- George Institute for Global Health (CN)
- Intensive Care National Audit & Research Centre (GB)
- Vanderbilt Health (US)
- Austin Health (AU)
- Monash University (AU)
- Medical University of Vienna (AT)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Intensive Care Medicine
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1007/s00134-025-08217-0
- Citations
- 1
- Primary Topic
- Intensive Care Unit Cognitive Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.55
Funders
- National Institutes of Health
- National Health and Medical Research Council
- National Center for Advancing Translational Sciences