Intracellular IL-24 ameliorates lipid metabolic disorders in metabolic dysfunction-associated steatohepatitis by restoring the autophagy-lysosome pathway
IL-24 preferentially utilizes the IL-22R1/IL-20R2 receptor complex to modulate the AMPK/mTOR/TFEB axis, thereby inducing autophagic-lysosomal activation, regulating glucose and lipid metabolism, and ameliorating hepatic lipid accumulation in MASH. These findings highlight IL-24 as a novel therapeutic target for MASH.
Authors
- Shaoya Li (ORCID: https://orcid.org/0000-0001-6917-4867)
- Yuhu He (ORCID: https://orcid.org/0000-0002-4814-1369)
- Yimin Mao (ORCID: https://orcid.org/0000-0002-2928-3425)
- Mengjiao Sun (ORCID: https://orcid.org/0000-0002-1817-9729)
- C. Zhang
- Yuemin Nan (ORCID: https://orcid.org/0000-0003-4192-099X)
- Yukai Chen (ORCID: https://orcid.org/0000-0002-9762-3022)
- Jiawei Cui (ORCID: https://orcid.org/0009-0003-5458-3555)
- Yue Shi (ORCID: https://orcid.org/0000-0002-0318-2861)
- Qianqian Zheng (ORCID: https://orcid.org/0009-0009-1875-5026)
- Zhenhai Lin
- Ying Zhang (ORCID: https://orcid.org/0000-0001-5476-1524)
Institutions
- Hebei Medical University (CN)
- Hebei University of Science and Technology (CN)
- Third Hospital of Hebei Medical University (CN)
- Hebei Science and Technology Department (CN)
Publication Details
- Journal
- Cellular and Molecular Life Sciences
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1007/s00018-025-05940-1
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00