Multiline treatment of primary cutaneous adenoid cystic carcinoma with multiple metastases: a case report and literature review
This case highlights an unusually aggressive clinical course of PCACC with rapid progression to widespread metastatic disease shortly after definitive local treatment. Given the rarity of metastatic PCACC, this report contributes valuable insight into its natural history, diagnostic approach, and therapeutic challenges. It underscores the need for heightened clinical awareness and further research into effective systemic treatment strategies for advanced PCACC.
Authors
- Xiaolong Chang
- Furong Hao (ORCID: https://orcid.org/0000-0002-5402-0109)
- Chunyan Zhang
- Jianwen Li (ORCID: https://orcid.org/0000-0002-0464-8694)
- Xiaotao Geng (ORCID: https://orcid.org/0000-0001-6828-6189)
- Daqing Sun (ORCID: https://orcid.org/0000-0002-4311-3481)
- Huimin Sun (ORCID: https://orcid.org/0000-0002-2892-5596)
Institutions
- Weifang Medical University (CN)
- Weifang People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-11-25
- DOI
- https://doi.org/10.3389/fonc.2025.1669171
- Primary Topic
- Salivary Gland Tumors Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00