Multiple tail vein injections of adipose-derived mesenchymal stem cells ameliorate allergic rhinitis in mice: superior efficacy of prolonged regimens
Systemic ADSC delivery through the tail vein alleviated AR in mice. Extended multi-injection schedules produced greater benefit. ADSCs represent a promising systemic immunomodulatory therapy for AR, with enhanced efficacy under longer treatment cycles.
Authors
- Fei He (ORCID: https://orcid.org/0000-0002-1165-3248)
- Zhengliang Gao (ORCID: https://orcid.org/0000-0001-5788-4095)
- Shaoqing Yu (ORCID: https://orcid.org/0000-0003-2208-4535)
- Kai Fan (ORCID: https://orcid.org/0000-0002-7586-4896)
- Ju Lai
- Yutong Xie
- Keqiang Zuo (ORCID: https://orcid.org/0000-0003-1202-8652)
- Lian Wang (ORCID: https://orcid.org/0000-0002-8793-7335)
- Jiacheng Zhang (ORCID: https://orcid.org/0000-0002-3260-4541)
- Yalei Dai
- Wenhan Yang (ORCID: https://orcid.org/0009-0001-5903-418X)
- Zhiyu Pan (ORCID: https://orcid.org/0000-0002-9310-329X)
Institutions
- Tongji University (CN)
- Jinggangshan University (CN)
- China-Japan Friendship Hospital (CN)
- Henan University Huaihe Hospital and Huaihe Clinical Institute (CN)
- Shanghai FRP Research Institute (China) (CN)
- Kaifeng University (CN)
- Tongji Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-25
- DOI
- https://doi.org/10.3389/fimmu.2025.1678927
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 0.00