Rapidly Progressive Multiple System Atrophy—Cerebellar Type in a 52‐Year‐Old Woman: Diagnostic Challenges in a Resource‐Limited Setting

Multiple system atrophy (MSA) is a progressive adult-onset neurodegenerative disorder that manifests as a variable combination of cerebellar, parkinsonian, and autonomic dysfunctions. We report a case of a 52-year-old woman who presented with rapidly progressive gait ataxia, dysarthria, orthostatic hypotension, and urinary urgency. MRI of the brain demonstrated pontocerebellar atrophy with the characteristic "hot cross bun" sign, supporting a diagnosis of Multiple System Atrophy-cerebellar type (MSA-C). Despite receiving levodopa and supportive therapy, the symptoms progressed over 8 months, highlighting the unusually rapid disease course. This case highlights the diagnostic value of targeted clinical assessment and MRI when advanced confirmatory tests are inaccessible, underscoring the importance of early recognition and multidisciplinary symptom management in resource-constrained settings.

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Publication Details

Journal
Clinical Case Reports
Published
2025-11-24
DOI
https://doi.org/10.1002/ccr3.71529
Primary Topic
Genetic Neurodegenerative Diseases
Type
article
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article

Rapidly Progressive Multiple System Atrophy—Cerebellar Type in a 52‐Year‐Old Woman: Diagnostic Challenges in a Resource‐Limited Setting

Ameesh Panda, Mihirkumar P Parmar, S. Nimmagadda, S Mohammed et al.
Clinical Case Reports
Genetic Neurodegenerative Diseases
article

Rapidly Progressive Multiple System Atrophy—Cerebellar Type in a 52‐Year‐Old Woman: Diagnostic Challenges in a Resource‐Limited Setting

Ameesh Panda, Mihirkumar P Parmar, S. Nimmagadda, S Mohammed, Tejasvini A. Patel, Khushi V. Singh, P. Patel, Sonika Gopathoti, Rarigela Rohith
article en

Abstract

Multiple system atrophy (MSA) is a progressive adult-onset neurodegenerative disorder that manifests as a variable combination of cerebellar, parkinsonian, and autonomic dysfunctions. We report a case of a 52-year-old woman who presented with rapidly progressive gait ataxia, dysarthria, orthostatic hypotension, and urinary urgency. MRI of the brain demonstrated pontocerebellar atrophy with the characteristic "hot cross bun" sign, supporting a diagnosis of Multiple System Atrophy-cerebellar type (MSA-C). Despite receiving levodopa and supportive therapy, the symptoms progressed over 8 months, highlighting the unusually rapid disease course. This case highlights the diagnostic value of targeted clinical assessment and MRI when advanced confirmatory tests are inaccessible, underscoring the importance of early recognition and multidisciplinary symptom management in resource-constrained settings.

Clinical Case ReportsVol. 13(12)
Siddhartha Medical College (IN), Gandhi Medical College & Hospital (IN), Gujarat Cancer Society (IN), Government Medical College (IN), Dhaka Medical College and Hospital (BD)
Openalex Percentile: Top 61%
Genetic Neurodegenerative Diseases
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