Pediatric dentinogenic ghost cell tumor: a case report and review of the literature

Dentinogenic ghost cell tumor (DGCT) is a rare odontogenic neoplasm that presents with nonspecific clinical manifestations and imaging features. It is more prevalent in elderly patients, with cases in children being extremely rare. This article presents a case study of a 10-year-old male patient who exhibited symptoms of swelling and pain in the left cheek for a duration of two weeks. Cone beam computed tomography (CBCT) demonstrated a hypodense lesion involving the left maxilla, with extension into the maxillary sinus and buccal cortical expansion. The patient underwent decompression, and histopathological examination of the intraoperative specimen suggested a diagnosis of calcifying odontogenic cyst (COC). One year after decompression, the patient underwent a tumor resection and the diagnosis of DGCT was confirmed by the post-operative pathology. Six months after tumor resection, CBCT showed complete bone remodeling in the lesion area. The patient is currently undergoing regular follow-up. This case provides an important reference for the diagnosis and treatment of pediatric DGCT, helping clinicians to develop individualised treatment plans.

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Publication Details

Journal
Frontiers in Oncology
Published
2025-11-25
DOI
https://doi.org/10.3389/fonc.2025.1665311
Primary Topic
Oral and Maxillofacial Pathology
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article
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article

Pediatric dentinogenic ghost cell tumor: a case report and review of the literature

Hongsheng Tian, Jingchao Han, Linlin Wang, Jianli Xie
Frontiers in Oncology
Oral and Maxillofacial Pathology
article

Pediatric dentinogenic ghost cell tumor: a case report and review of the literature

Hongsheng Tian, Jingchao Han, Linlin Wang, Jianli Xie
article en

Abstract

Dentinogenic ghost cell tumor (DGCT) is a rare odontogenic neoplasm that presents with nonspecific clinical manifestations and imaging features. It is more prevalent in elderly patients, with cases in children being extremely rare. This article presents a case study of a 10-year-old male patient who exhibited symptoms of swelling and pain in the left cheek for a duration of two weeks. Cone beam computed tomography (CBCT) demonstrated a hypodense lesion involving the left maxilla, with extension into the maxillary sinus and buccal cortical expansion. The patient underwent decompression, and histopathological examination of the intraoperative specimen suggested a diagnosis of calcifying odontogenic cyst (COC). One year after decompression, the patient underwent a tumor resection and the diagnosis of DGCT was confirmed by the post-operative pathology. Six months after tumor resection, CBCT showed complete bone remodeling in the lesion area. The patient is currently undergoing regular follow-up. This case provides an important reference for the diagnosis and treatment of pediatric DGCT, helping clinicians to develop individualised treatment plans.

Frontiers in OncologyVol. 15
Shandong University of Traditional Chinese Medicine (CN), Jinan Stomatological Hospital (CN), Affiliated Hospital of Shandong University of Traditional Chinese Medicine (CN)
Openalex Percentile: Top 49%
Oral and Maxillofacial Pathology
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Pediatric dentinogenic ghost cell tumor: a case report and review of the literature — Hongsheng Tian, Jingchao Han, et al. · Frontiers in Oncology (2025) | TGRS Research Map | TGRS