Silencing Clusterin Could Attenuate the Cell Properties of HCV Core Protein-Expressing HCC Cell Line
CLU-mediated regulation of apoptosis and invasion pathways emerges as a critical mechanism in HCC progression according to our data. Our findings demonstrated that CLU is a promising therapeutic target for HCV-associated HCC, providing novel perspectives for developing targeted treatments against this aggressive cancer.
Authors
- Nanqing Fu (ORCID: https://orcid.org/0009-0006-2071-6307)
- Fang Han (ORCID: https://orcid.org/0000-0002-8743-8763)
- Lingdi Liu (ORCID: https://orcid.org/0000-0003-4286-5603)
- Shiming Dong (ORCID: https://orcid.org/0000-0003-3621-1443)
- Zhenzhen Zhao
- Chengde Cui
- Suhua Zang
- Yuemin Nan (ORCID: https://orcid.org/0000-0003-4192-099X)
- Jing Cui (ORCID: https://orcid.org/0000-0002-1496-1828)
- Qingshan Zhang (ORCID: https://orcid.org/0009-0001-2559-5253)
- Weiguang Ren
Institutions
- Hebei Medical University (CN)
- Third Hospital of Hebei Medical University (CN)
- Hebei Seismological Bureau (CN)
Publication Details
- Journal
- Digestive Diseases and Sciences
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1007/s10620-025-09560-4
- Citations
- 1
- Primary Topic
- Clusterin in disease pathology
- Type
- article
- Field-Weighted Citation Impact
- 1.05