Independent component analysis of resting-state fMRI identifies regions associated with seizure freedom after laser interstitial thermal therapy for temporal lobe epilepsy
These findings highlight the potential of pre-operative rs-fMRI as a prognostic tool for identifying TLE patients more likely to benefit from LITT. Further validation in larger cohorts is warranted to confirm these results and optimize patient selection for surgical interventions.
Authors
- Michael R. Sperling (ORCID: https://orcid.org/0000-0003-0708-6006)
- Caio M. Matias (ORCID: https://orcid.org/0000-0001-6101-1158)
- Jingya Miao (ORCID: https://orcid.org/0000-0001-6482-5384)
- Joseph I. Tracy (ORCID: https://orcid.org/0000-0001-5260-3290)
- Mahdi Alizadeh (ORCID: https://orcid.org/0000-0003-1923-0407)
- Christopher Skidmore (ORCID: https://orcid.org/0000-0002-9939-4307)
- Kevin J. Hines
- Ashwini Sharan (ORCID: https://orcid.org/0000-0002-4759-6097)
- Chengyuan Wu
Institutions
- Thomas Jefferson University (US)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2025-11-25
- DOI
- https://doi.org/10.3389/fneur.2025.1675066
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00