Characterization of the Porcine Cardiac Conduction System and Electrocardiogram: Implications for Using the Pig in Translational Arrhythmia Research

These results suggest that in the pig, the mean electrical axis is influenced more by the presence of an intramural Purkinje fiber network rather than by left ventricular mass as seen in humans. This study underscores important species-specific differences in ventricular electrical activation and highlights the need for caution when extrapolating electrophysiological findings from porcine models to humans.