A contemporary review on heart failure with improved ejection fraction
Heart failure is a complex condition caused by various etiologies that reduce cardiac output or increase cardiac pressures. It is classified by left ventricular ejection fraction, a key prognostic factor. New therapies, devices, and better management of secondary causes have improved outcomes. A recently identified group-those with heart failure and improved ejection fraction-shows better prognosis. This review explores its definition, causes, clinical significance, and management strategies.
Authors
- Weiss Aa
- Muzamil Khawaja (ORCID: https://orcid.org/0000-0001-8837-1057)
- Biykem Bozkurt (ORCID: https://orcid.org/0000-0002-6362-0253)
- W.H. Wilson Tang (ORCID: https://orcid.org/0000-0002-8335-735X)
- Errol Moras
- Carl J. Lavie (ORCID: https://orcid.org/0000-0003-3906-1911)
- Gregg C. Fonarow (ORCID: https://orcid.org/0000-0002-3192-8093)
- Scott Eisenberg
- Mario Rodríguez Rodríguez (ORCID: https://orcid.org/0000-0002-4587-3863)
- Lingling Wu (ORCID: https://orcid.org/0000-0002-5051-5040)
- Chayakrit Krittanawong (ORCID: https://orcid.org/0000-0002-2514-8664)
- Ambre Flowers
Institutions
- Brigham and Women's Hospital (US)
- Houston Methodist (US)
- Barnes-Jewish Hospital (US)
- Cleveland Clinic (US)
- Emory University (US)
- University of California, Los Angeles (US)
- Washington University in St. Louis (US)
- Ochsner Medical Center (US)
- University of Alabama at Birmingham (US)
- Los Angeles Medical Center (US)
Publication Details
- Journal
- npj Cardiovascular Health
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1038/s44325-025-00093-3
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.00