Time- and dose-dependent high-sensitivity cardiac troponin-T to improve outcome prediction after TAVI: a multicenter cohort study
The dichotomized VARC-3 definition of PPMI showed no prognostic value. Modelling hs-cTnT as continuous and time-dependent revealed a dynamic risk trajectory after TAVI. Incorporating these non-linear and time-dependent effects into risk prediction models may improve clinical decision-making and personalize post-procedural surveillance.
Authors
- Gregor Leibundgut (ORCID: https://orcid.org/0000-0002-0122-5397)
- Ivo Strebel (ORCID: https://orcid.org/0000-0001-9976-4112)
- Thorald Stolte (ORCID: https://orcid.org/0000-0001-9840-7818)
- Philipp Breitbart (ORCID: https://orcid.org/0000-0002-7390-5287)
- Pedro López‐Ayala (ORCID: https://orcid.org/0000-0002-7787-0640)
- Felix Mahfoud (ORCID: https://orcid.org/0000-0002-4425-549X)
- Ramona Schmitt
- Jakob Johannes Reichl (ORCID: https://orcid.org/0009-0007-2497-7587)
- Dirk Westermann (ORCID: https://orcid.org/0000-0002-7542-1956)
- Tau Hartikainen (ORCID: https://orcid.org/0000-0003-0966-7250)
- Thomas Nestelberger (ORCID: https://orcid.org/0000-0003-2173-5738)
- Max Wagener (ORCID: https://orcid.org/0000-0002-7970-8989)
- Felix Goetzinger
- Jasper Boeddinghaus (ORCID: https://orcid.org/0000-0003-4404-4956)
- Christian Müller (ORCID: https://orcid.org/0000-0002-1120-6405)
- Philipp Ruile (ORCID: https://orcid.org/0009-0009-1822-3038)
Institutions
- University of Basel (CH)
- University Hospital of Basel (CH)
- Hospital Base (CL)
- Universitäts-Herzzentrum Freiburg-Bad Krozingen (DE)
Publication Details
- Journal
- Clinical Research in Cardiology
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1007/s00392-025-02808-z
- Primary Topic
- Acute Myocardial Infarction Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universität Basel