HGMT: a database of human gut microbiota for tumors and immunotherapy response
HGMT is a database designed to analyze, explore, and visualize gut microbiomes from diverse tumor types. We process metagenomic datasets from 18,630 stool samples across 37 tumor types, including 2,207 samples from immunotherapy-treated patients across 12 tumor types. HGMT provides an interactive portal for querying taxonomic and functional profiles, visualizing cross-dataset differential abundance taxa in tumors, and identifying their pan-tumor associations. Our analysis reveals the capability of gut microbiota in diagnosing gastrointestinal tumors and predicting immunotherapy response for non-small cell lung carcinoma. HGMT represents a valuable resource for investigating the roles of gut microbiota in tumors and immunotherapy response.
Authors
- Yucheng Yang (ORCID: https://orcid.org/0000-0002-6873-5279)
- Senying Lai (ORCID: https://orcid.org/0000-0003-0557-2393)
- C. F. Xu (ORCID: https://orcid.org/0009-0005-8484-9849)
- Longhao Jia (ORCID: https://orcid.org/0000-0002-3490-840X)
- Zi-Chao Zhang (ORCID: https://orcid.org/0000-0001-5747-3093)
- Xing‐Ming Zhao (ORCID: https://orcid.org/0000-0002-4531-3970)
- Jinxin Liu (ORCID: https://orcid.org/0000-0002-5081-7882)
- Wei‐Hua Chen (ORCID: https://orcid.org/0000-0001-5160-4398)
- Jinglong Zhang (ORCID: https://orcid.org/0000-0001-6795-1423)
- Mingyu Wang (ORCID: https://orcid.org/0009-0002-9177-9509)
Institutions
- Zhejiang Sci-Tech University (CN)
- Sun Yat-sen University (CN)
- Fudan University (CN)
- Shanghai Institute for Science of Science (CN)
- Huzhou Central Hospital (CN)
- Chinese Institute for Brain Research (CN)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Obstetrics and Gynecology Hospital of Fudan University (CN)
- Shanghai Center for Brain Science and Brain-Inspired Technology (CN)
- Huazhong University of Science and Technology (CN)
- Jining Medical University (CN)
Publication Details
- Journal
- Genome biology
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1186/s13059-025-03865-3
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Fudan University
- Shanghai Municipal Education Commission
- Science and Technology Commission of Shanghai Municipality