Sepsis management in the antimicrobial resistance era
In severe cases progressing to septic shock, timely and accurate diagnosis is critical. It is mandatory to make every effort to shorten the time to diagnosis in order to enable appropriate supportive care and targeted antibiotic therapy. In this context, novel microbiological diagnostic methods should be considered to facilitate early detection of multidrug-resistant organisms and promote the initiation of effective empiric antibiotic treatment. Furthermore, the development of new molecules with innovative mechanisms of action, alongside therapeutic strategies targeting specific patterns of the immune response, is expected to improve the patient survival rates.
Authors
- Anna Maria Spera (ORCID: https://orcid.org/0000-0003-1292-3040)
- Tiziana Ascione (ORCID: https://orcid.org/0000-0002-0422-690X)
- Valeria Conti (ORCID: https://orcid.org/0000-0001-6964-2739)
- Chiara D’Amore
- Gianluigi Franci
- Francesco Antonio Salzano (ORCID: https://orcid.org/0000-0003-4090-8120)
- Silvano Esposito (ORCID: https://orcid.org/0000-0001-7398-3624)
- Pasquale Pagliano (ORCID: https://orcid.org/0000-0002-8109-0655)
Institutions
- University of Salerno (IT)
- Fatebenefratelli Hospital (IT)
- Ospedali Riuniti San Giovanni di Dio e Ruggi d'Aragona (IT)
Publication Details
- Journal
- Expert Review of Anti-infective Therapy
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1080/14787210.2025.2595466
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00