Uncoupling protein 2 and signal transducer and activator of transcription 1 are targets of human papillomavirus oncoproteins and may be prognostic markers for cervical cancer development
Our findings demonstrate that HPV oncoproteins modulate the expression of UCP2 and STAT1. These proteins may serve as valuable prognostic markers for patients with precursor cervical lesions, and UCP2 expression, in particular, could be beneficial for predicting outcomes in cervical cancer patients.
Authors
- Enrique Boccardo (ORCID: https://orcid.org/0000-0003-1900-0273)
- Ana Paula Lepique (ORCID: https://orcid.org/0000-0002-4707-2912)
- Vanesca de Souza Lino (ORCID: https://orcid.org/0000-0002-4613-5475)
- Noely Paula Cristina Lorenzi (ORCID: https://orcid.org/0000-0001-8144-1745)
- Laura Sichero (ORCID: https://orcid.org/0000-0002-7999-5818)
- Giana Mota (ORCID: https://orcid.org/0000-0002-3136-2413)
- Maria Luiza Nogueira Dias Genta (ORCID: https://orcid.org/0000-0001-6669-7179)
- Luisa L. Villa (ORCID: https://orcid.org/0000-0003-4074-2335)
- Mariana Carmezim Beldi (ORCID: https://orcid.org/0000-0001-8585-6593)
- Edmund Chada Baracat (ORCID: https://orcid.org/0000-0003-0111-9030)
- Márcia Farina Kamilos (ORCID: https://orcid.org/0000-0002-9852-4341)
- Maricy Tacla (ORCID: https://orcid.org/0000-0002-2712-2724)
- Fabiane Cristina Colunna
- Jordy Alexander Lasso Larco
Institutions
- Universidade de São Paulo (BR)
- Instituto do Câncer do Estado de São Paulo (BR)
- Hospital Heliópolis (BR)
- Hospital Universitário da Universidade de São Paulo (BR)
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-11-24
- DOI
- https://doi.org/10.3389/fonc.2025.1689058
- Primary Topic
- Cervical Cancer and HPV Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00