Statins and uterine fibroids: Potential for a novel therapeutic approach
Statins have demonstrated anti-proliferative and pro-apoptotic effects on uterine fibroids, resulting in symptomatic improvement and reduction in fibroid volume in clinical studies. However, given the paucity of evidence, it is challenging to conclude on the comparative efficacy, the most appropriate type of statin, the optimal dosing regimen, and the treatment duration, thereby creating a potential research gap. Therefore, we recommend well-planned prospective studies to establish the role of statins in the management of uterine fibroids.
Authors
- I. A. Jayawardane (ORCID: https://orcid.org/0000-0001-6568-8035)
- Shreenika De Silva Weliange (ORCID: https://orcid.org/0000-0003-2429-8860)
- N. M. C. L. Nishshanka (ORCID: https://orcid.org/0009-0006-6055-551X)
- T. D. K. M. Jayasingha (ORCID: https://orcid.org/0009-0005-3767-9541)
- D. M. C. S. Jayasundara (ORCID: https://orcid.org/0000-0003-4100-123X)
Institutions
- Lanka Hospitals (LK)
- Ministry of Health, Nutrition and Indigenous Medicine (LK)
- University of Colombo (LK)
Publication Details
- Journal
- International Journal of Gynecology & Obstetrics
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1002/ijgo.70664
- Primary Topic
- Uterine Myomas and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00