Selinexor, a selective inhibitor of nuclear export, shows anti-proliferative and anti-migratory effects on male germ cells in vitro
The data suggest that SLX may decrease cell viability, induce apoptosis, inhibit cell migration and increase DNA damage and cellular stress in male germ cells. Given these effects, SLX should be carefully examined for its potential reproductive toxicity. Further studies are warranted to explore its long-term impact on male fertility.
Authors
- Hülya Öztatlıcı (ORCID: https://orcid.org/0000-0002-6749-9665)
- Büşra Şen (ORCID: https://orcid.org/0000-0003-4089-5243)
- Mustafa Öztatlıcı (ORCID: https://orcid.org/0000-0001-9914-7122)
- Rukiye Betül Çolaksel (ORCID: https://orcid.org/0009-0002-5256-1259)
- Parmila Rahmat Zada (ORCID: https://orcid.org/0009-0002-2133-7035)
Institutions
- Gaziantep University (TR)
Publication Details
- Journal
- BMC Pharmacology and Toxicology
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1186/s40360-025-01034-7
- Primary Topic
- Nuclear Structure and Function
- Type
- article
- Field-Weighted Citation Impact
- 0.00