Identifying sleep patterns as a synthetic signature in metabolic comorbidities using a stratified medicine approach
Sleep factors aggregated into three prevalent sleep patterns, with strong internal correlations observed within each pattern. PSP was associated with increased odds of metabolic comorbidities, with this association being pronounced in all participants and men. Notably, BMI served as a partial mediator of this relationship in the male subgroup. ISP showed significant associations with T2DM and NAFLD, highlighting their clinical relevance. These findings emphasize the role of sleep in metabolic health and support the need for longitudinal sleep interventions and strategies to improve sleep conditions.
Authors
- Zhuoqing Wu (ORCID: https://orcid.org/0000-0003-2415-5202)
- Suying Ding (ORCID: https://orcid.org/0000-0002-2649-8332)
- Jingfeng Chen (ORCID: https://orcid.org/0009-0005-2898-1490)
- Qian Qin (ORCID: https://orcid.org/0000-0002-8464-0624)
- S K Zhang (ORCID: https://orcid.org/0009-0005-7365-7024)
- Lin Wang (ORCID: https://orcid.org/0009-0000-5151-2506)
Institutions
- Dalian University of Technology (CN)
- Zhengzhou University (CN)
- Henan Provincial Institute of Occupational Health (CN)
- Dalian University (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- BMC Public Health
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1186/s12889-025-25351-y
- Citations
- 1
- Primary Topic
- Sleep and related disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.12
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Zhengzhou University