Mechanism of ECM Stiffness-Integrin-Hippo-ABCG1 axis in regulating ferroptosis and targeted nanodrug intervention in LUAD
Our findings revealed a novel mechanism by which ECM stiffness regulated ferroptosis via the Integrin-Hippo-ABCG1 pathway in LUAD. Nanodrugs designed to target ABCG1 demonstrate significant potential for future LUAD therapy by resensitizing tumors to ferroptosis (Fig. 1).
Authors
- Tinghua Hu (ORCID: https://orcid.org/0000-0002-8506-6302)
- Tingting Li (ORCID: https://orcid.org/0000-0001-7331-9619)
- Shuo Yu (ORCID: https://orcid.org/0000-0002-7988-0551)
- Tingting Liu (ORCID: https://orcid.org/0000-0003-3671-2782)
- Guangdong Wang (ORCID: https://orcid.org/0000-0002-7557-5154)
- Zhihong Shi (ORCID: https://orcid.org/0000-0002-5743-5158)
- Wenwen Ji
- Lu Zhang (ORCID: https://orcid.org/0009-0001-0784-6047)
Institutions
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Second Affiliated Hospital of Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Respiratory Research
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1186/s12931-025-03403-6
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00