Targeting Cancer with Redox Catalysis: Manganese Porphyrins and Ascorbate Synergistically Induce Selective Oxidative Stress and Necrotic Cell Death
MnTPPS and MnF<sub>2</sub>BMet enhance extracellular oxidation of ascorbate and subsequent ROS production, leading to selective oxidative-stress-mediated cancer cell death. This study supports the potential of MnPs-ASC redox catalysis as a complementary oxidative-stress-based anticancer strategy and highlights the need for further mechanistic and structure-activity investigations.
Authors
- Sławomir Lasota (ORCID: https://orcid.org/0000-0002-9477-5338)
- Maciej Pudełek (ORCID: https://orcid.org/0000-0002-1893-3066)
- Zbigniew Madeja (ORCID: https://orcid.org/0000-0002-5523-1215)
- Sylwia Noga (ORCID: https://orcid.org/0000-0003-4475-187X)
- Jarosław Czyż (ORCID: https://orcid.org/0000-0001-6779-7630)
- Michał Rąpała
- Janusz M. Dąbrowski (ORCID: https://orcid.org/0000-0002-8791-7035)
Institutions
- Jagiellonian University (PL)
Publication Details
- Journal
- Cancers
- Published
- 2025-11-22
- DOI
- https://doi.org/10.3390/cancers17233736
- Primary Topic
- Metal-Catalyzed Oxygenation Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00