Novel synthetic strategy for aromatic ether coumarin derivatives and evaluation of anti-allergic potential
Aromatic ether coumarins can be efficiently constructed via the oxidation of hydroxycoumarins with hypervalent iodine compounds. Compound 6 inhibited both IgE-induced and calcium ionophore (A23187)-mediated degranulation of BMMCs, warranting further in-depth investigation into its pharmacogenetic and therapeutic potential.
Authors
- Xiaoxia Mao (ORCID: https://orcid.org/0000-0003-1904-9309)
- Yuying Zhang (ORCID: https://orcid.org/0009-0001-2658-8573)
- Xiaoyue Liu (ORCID: https://orcid.org/0000-0002-1087-1235)
- Dejun Zhou (ORCID: https://orcid.org/0000-0001-6432-1493)
Institutions
- Chengde Medical University (CN)
Publication Details
- Journal
- BMC Chemistry
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1186/s13065-025-01687-9
- Primary Topic
- Oxidative Organic Chemistry Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00