Long‐term predictors of seizure outcome after anterior temporal lobectomy in unilateral hippocampal sclerosis: A 281‐patient cohort with mean 10‐year follow‐up
In this large single-surgeon cohort with one of the longest follow-up durations reported, most patients with unilateral HS achieved durable seizure freedom after ATL. Status epilepticus, consistent ictal localization to the operated temporal lobe, and concordant preoperative neuropsychological deficit emerged as robust long-term predictors. These findings reinforce the value of detailed presurgical evaluation-particularly ictal EEG concordance and neuropsychological lateralization-in optimizing surgical counseling, risk stratification, and patient selection.
Authors
- Jeana Torres Corso Duarte
- Ricardo Silva Centeno (ORCID: https://orcid.org/0000-0002-3340-8243)
- Leonardo Favi Bocca (ORCID: https://orcid.org/0000-0003-4809-0159)
- Mirian Salvadori Bittar Guaranha (ORCID: https://orcid.org/0000-0003-0654-9283)
- Henrique Carrete (ORCID: https://orcid.org/0000-0003-2972-163X)
- Elza Márcia Targas Yacubian (ORCID: https://orcid.org/0000-0001-8367-0189)
- Maria Helena Silva Noffs (ORCID: https://orcid.org/0000-0003-1464-4512)
- Luís Otávio Sales Ferreira Caboclo (ORCID: https://orcid.org/0009-0001-4956-5542)
- Thiago Pereira Rodrigues (ORCID: https://orcid.org/0000-0001-6249-3961)
- Neide Barreira Alonso
Institutions
- Hospital Israelita Albert Einstein (BR)
- Universidade Federal de São Paulo (BR)
Publication Details
- Journal
- Epileptic Disorders
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1002/epd2.70139
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00