Multicentre investigation of <i>Wickerhamomyces anomalus</i> fungemia in India: emerging resistance and mechanistic insights
This multicentre study demonstrates the emergence of fluconazole-NWT W. anomalus in Indian hospitals, predominantly affecting neonates, with a high mortality. Resistance was associated with ERG11 mutations, efflux pump overexpression and biofilm formation. These findings highlight that the drug-resistant W. anomalus fungemia is an emerging concern.
Authors
- Shristi Verma
- Anjna Kumari (ORCID: https://orcid.org/0000-0002-4686-2453)
- Anup Ghosh (ORCID: https://orcid.org/0000-0002-0341-6680)
- Theun de Groot (ORCID: https://orcid.org/0000-0001-5841-6461)
- Shivaprakash Mandya Rudramurthy (ORCID: https://orcid.org/0000-0002-9097-9253)
- Eelco F. J. Meijer (ORCID: https://orcid.org/0000-0002-0226-024X)
- Bram Spruijtenburg (ORCID: https://orcid.org/0000-0002-6734-361X)
- Munesh Kumar Gupta (ORCID: https://orcid.org/0000-0002-2107-1727)
- Gagandeep Singh (ORCID: https://orcid.org/0000-0002-3169-8419)
- Jacques F. G. M. Meis (ORCID: https://orcid.org/0000-0003-3253-6080)
- Harsimran Kaur (ORCID: https://orcid.org/0000-0002-4871-8113)
- Shreya Singh (ORCID: https://orcid.org/0000-0002-8859-9163)
- Ragini Tilak
- Immaculata Xess
Institutions
- Radboud University Nijmegen (NL)
- Radboud University Medical Center (NL)
- Radboud Institute for Molecular Life Sciences (NL)
- Canisius-Wilhelmina Ziekenhuis (NL)
- Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (DE)
- Post Graduate Institute of Medical Education and Research (IN)
- Institute of Medical Sciences (IN)
- All India Institute of Medical Sciences (IN)
- Banaras Hindu University (IN)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1093/jac/dkaf420
- Primary Topic
- Fungal Infections and Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00