Integrated scRNA-seq and transcriptome analyses uncover the effects of UBE2H on the immune microenvironment regulation in pancreatic cancer
This study revealed the presence of a UBE2H+ cell population within the pancreatic ductal cell niche and analyzed the inhibition of UBE2H on the immune microenvironment of pancreatic cancer through single-cell sequencing and in vivo experiments, providing important clues for the formation of "cold" tumors in pancreatic cancer and opening new directions for exploring new treatment strategies.
Authors
- Fuxin Huang
- Jike Fang
- Baohua Hou (ORCID: https://orcid.org/0000-0002-4239-1367)
- Jinhui Wei
- Shanzhou� Huang (ORCID: https://orcid.org/0000-0002-7575-5841)
- Qiang Li (ORCID: https://orcid.org/0000-0002-4897-1012)
- Chuanzhao Zhang (ORCID: https://orcid.org/0000-0002-9782-6970)
- Zhongyan Zhang
- Yue Chen (ORCID: https://orcid.org/0009-0009-1727-8758)
Institutions
- Guangdong General Hospital (CN)
- Guangdong Academy of Medical Sciences (CN)
- Gaozhou People's Hospital (CN)
- Southern Medical University (CN)
- South China University of Technology (CN)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1186/s12935-025-04059-4
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00