Coptisine regulates PI3K/AKT pathway to block bladder cancer progression: a study based on network pharmacology, in vitro and in vivo assays
COP may be a natural inhibitor for AKT1, GSK3B, CASP3, TNF and CCND1. COP represses PI3K/AKT pathway to suppress the progression of bladder cancer.
Authors
- Jiangqiao Zhou (ORCID: https://orcid.org/0000-0002-6118-0020)
- Xiaohui Yu (ORCID: https://orcid.org/0000-0001-8170-2327)
- Jie Li (ORCID: https://orcid.org/0000-0002-6175-3167)
Institutions
- Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
Publication Details
- Journal
- Hereditas
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1186/s41065-025-00600-7
- Primary Topic
- Cancer, Stress, Anesthesia, and Immune Response
- Type
- article
- Field-Weighted Citation Impact
- 0.00