Eschweilenol C and subfractions from Terminalia plants disrupt haemoglobin metabolism, inhibiting Plasmodium falciparum growth at rings and trophozoite stages
This study identifies eschweilenol C as a promising candidate for malaria drug discovery efforts and its significance for further exploration in the context of the emergence of artemisinin-resistant parasites in Africa.
Authors
- Feroz Khan (ORCID: https://orcid.org/0000-0002-2704-5925)
- Steven Collins Njonté Wouamba (ORCID: https://orcid.org/0000-0002-7398-8203)
- Fabrice Fekam Boyom (ORCID: https://orcid.org/0000-0002-3147-364X)
- Mariscal Brice Tchatat Tali (ORCID: https://orcid.org/0000-0002-3003-5234)
- Darline Dize (ORCID: https://orcid.org/0000-0003-3387-4102)
- Cedric Derick Jiatsa Mbouna (ORCID: https://orcid.org/0000-0002-9501-6958)
- Aafreen Zehra
- Jean Claude Tchouankeu (ORCID: https://orcid.org/0000-0002-5202-0316)
- Boniface Pone Kamdem (ORCID: https://orcid.org/0000-0002-4982-0507)
- Siméon F. Kouam (ORCID: https://orcid.org/0000-0003-0191-0527)
- Aubin Youbi Kamche (ORCID: https://orcid.org/0009-0001-4061-2912)
- Guy Paulin Kemayou Mouthe
Institutions
- Department of Agriculture, Land Reform and Rural Development (ZA)
- Université de Yaoundé I (CM)
- African Institute of Biomedical Science and Technology (ZW)
- Ministry of Scientific Research and Innovation (CM)
- Central Institute of Medicinal and Aromatic Plants (IN)
Publication Details
- Journal
- Malaria Journal
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1186/s12936-025-05445-z
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Medicines for Malaria Venture