Targeting of specific CCR5-G protein complexes underlies biased signaling by HIV-1 envelope glycoproteins
These findings reveal that CCR5 exists in a mosaic of distinct membrane-associated functional states, differentially accessed by viral and endogenous ligands. This spatial and signaling compartmentalization provides a mechanistic framework to understand CCR5's functional diversity in health and disease and highlights the potential for developing context-specific CCR5-targeted therapeutic strategies.
Authors
- Esther Kellenberger (ORCID: https://orcid.org/0000-0002-9320-4840)
- Véronique Pons (ORCID: https://orcid.org/0000-0001-5821-8481)
- Céline Galès (ORCID: https://orcid.org/0000-0002-4938-1583)
- Zhicheng Zhou (ORCID: https://orcid.org/0000-0001-9137-7951)
- Evi Kostenis (ORCID: https://orcid.org/0000-0001-8284-5514)
- Romain Gasser (ORCID: https://orcid.org/0000-0002-8565-1106)
- Bernard Lagane (ORCID: https://orcid.org/0000-0002-3459-7867)
- Célien Jacquemard
- Philippe Colin (ORCID: https://orcid.org/0000-0002-5552-8908)
- Théo Montagné
Institutions
- International Space University (FR)
- Centre National de la Recherche Scientifique (FR)
- University of Bonn (DE)
- Inserm (FR)
- Institut Pasteur (FR)
- Université Fédérale de Toulouse Midi-Pyrénées (FR)
- Toulouse Mathematics Institute (FR)
- Department of Virology (FR)
- Hôpital Saint-Louis (FR)
- Institut des Maladies Métaboliques et Cardiovasculaires (FR)
- Université de Strasbourg (FR)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1186/s12964-025-02508-1
- Primary Topic
- Chemokine receptors and signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Institut National de la Santé et de la Recherche Médicale
- Agence Nationale de Recherches sur le Sida et les Hépatites Virales
- Institut National de Physique Nucléaire et de Physique des Particules
- CHIST-ERA