Establishment and transcriptomic characterization of canine organoids from multiple tissues
These organoids begin to establish a platform for reverse translational research, reducing reliance on live animal testing. By leveraging genetically related donors, it highlights tissue-specific variations, facilitating applications in personalized medicine, disease modeling, and pharmacology to bridge veterinary and human research gaps.
Authors
- Dipak Kumar Sahoo (ORCID: https://orcid.org/0000-0003-3748-3395)
- Megan P. Caputo (ORCID: https://orcid.org/0009-0009-3277-5525)
- Jonathan P. Mochel (ORCID: https://orcid.org/0000-0002-0997-3111)
- Abigail Ralston (ORCID: https://orcid.org/0000-0002-2071-8349)
- Leila Bedos (ORCID: https://orcid.org/0000-0001-8633-1262)
- Eugene F. Douglass (ORCID: https://orcid.org/0000-0003-3418-9203)
- Vojtěch Gabriel (ORCID: https://orcid.org/0000-0003-2704-2297)
- Aleksandra Pawlak (ORCID: https://orcid.org/0000-0002-7449-1661)
- Karin Allenspach (ORCID: https://orcid.org/0000-0002-2168-5809)
- Kimberly Dao (ORCID: https://orcid.org/0000-0001-9008-396X)
- Hannah Wickham (ORCID: https://orcid.org/0000-0003-1395-2863)
- Pablo Enrique Piñeyro (ORCID: https://orcid.org/0000-0002-0884-7762)
- Sydney Honold (ORCID: https://orcid.org/0000-0001-7172-4418)
- Oscar E. Ospina (ORCID: https://orcid.org/0000-0001-5986-4207)
- Christopher Zdyrski (ORCID: https://orcid.org/0000-0002-7556-5298)
- William Bastian
- Leeann S. Aguilar Meza (ORCID: https://orcid.org/0000-0002-9785-4592)
- Hannah Nicholson
- M. Catucci
- Bryan J. Melvin (ORCID: https://orcid.org/0009-0007-8035-8756)
Institutions
- University of Georgia (US)
- Iowa State University (US)
- Wrocław University of Environmental and Life Sciences (PL)
- Moffitt Cancer Center (US)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-11-24
- DOI
- https://doi.org/10.3389/fcell.2025.1680376
- Citations
- 1
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 1.05