Comparative Transcriptomic Profiling of Mesenchymal Stem Cells from Distinct Tissue Origins and Isolation Methods Highlights the Stability and Immunomodulatory Signature of Umbilical Cord-Derived Smumf Cells
This study provides a comprehensive transcriptomic comparison of MSCs, highlighting the superior transcriptional stability, immunomodulatory capacity, and metabolic flexibility of fetal MSCs, particularly smumf cells. These findings underscore their potential as a reliable cell source for therapeutic applications and encourage further exploration of their clinical application.
Authors
- Kyungtaek Park (ORCID: https://orcid.org/0000-0003-0786-6969)
- Chris Hyunchul Jo (ORCID: https://orcid.org/0000-0002-6161-5442)
- Sungho Won (ORCID: https://orcid.org/0000-0001-5751-5089)
- Minji Lee (ORCID: https://orcid.org/0000-0003-3466-5257)
Institutions
- Seoul National University (KR)
- New Generation University College (ET)
- SNUH SMG-SNU Boramae Medical Center (KR)
- National University College (PR)
- Jeonbuk National University (KR)
Publication Details
- Journal
- Tissue Engineering and Regenerative Medicine
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1007/s13770-025-00765-2
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Seoul National University
- Korea Health Industry Development Institute
- Ministry of SMEs and Startups
- Ministry of Science and ICT, South Korea