Unraveling a mechanism underlying hepatitis E-associated kidney disease

The formation of glomerular IgG-HEV ORF2 immune complexes discovered here provides a mechanistic explanation of how the hepatotropic HEV can cause variable renal manifestations. These findings directly provide a tool for etiology-based diagnosis of hepatitis E-associated GN, establish hepatitis E-associated GN as a distinct entity, and suggest therapeutic implications.