Nanomaterials-Enhanced Electrochemical Biosensors for Epithelial Cancer Diagnosis: Recent Advances
In recent years, the interest in electrochemical biosensors has been constantly growing for epithelial cancer diagnosis and prognosis. The incorporation of the different nanomaterials as metal nanoparticles, magnetic nanoparticles, carbon nanomaterials, Metal-Organic Frameworks (MOFs), and nanocomposites, along with specific monoclonal antibodies, and nucleic acids (aptamers) has improved both sensitivity and specificity in these methodologies. In this review, we have presented examples of electrochemical biosensors for the determination of different epithelial cancer biomarkers. Based on numerous reports in the recent literature, we highlight the use of single and multiplexed analytical platforms for the quantification of epithelial cancer biomarkers. In addition, we outline potential development pathways, current challenges, and future prospects in the field of electrochemical immuno-, apta-, and genosensors.
Authors
- Juan Sáinz (ORCID: https://orcid.org/0000-0002-9355-2423)
- Gonzalo Tortella (ORCID: https://orcid.org/0000-0001-7069-7454)
- Matías Regiart (ORCID: https://orcid.org/0000-0001-9255-6222)
- Francisco G. Ortega (ORCID: https://orcid.org/0000-0003-0563-2237)
- Germán E. Gómez (ORCID: https://orcid.org/0000-0003-4963-5202)
- Martín A. Fernández‐Baldo (ORCID: https://orcid.org/0000-0003-0385-2391)
- Alba Marina Gimenez (ORCID: https://orcid.org/0000-0001-8251-1346)
Institutions
- Universidad de La Frontera (CL)
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Universidad de Granada (ES)
- Instituto de Investigación Biosanitaria de Granada (ES)
- Pfizer-University of Granada-Junta de Andalucía Centre for Genomics and Oncological Research (ES)
- Hospital Universitário da Universidade de São Paulo (BR)
- Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (ES)
- Institute of Biomedical Science (GB)
- Universitat de Barcelona (ES)
- National University of San Luis (AR)
Publication Details
- Journal
- Biosensors
- Published
- 2025-11-22
- DOI
- https://doi.org/10.3390/bios15120766
- Citations
- 1
- Primary Topic
- Advanced biosensing and bioanalysis techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Pfizer
- Universidad Nacional de San Luis
- Consejo Nacional de Investigaciones Científicas y Técnicas
- Universidad de Granada
- Centro Pfizer-Universidad de Granada-Junta de Andalucía de Genómica e Investigación Oncológic
- Agencia Nacional de Promoción Científica y Tecnológica
- Instituto de Salud Carlos III