Neuroprotective effects of ceftriaxone after severe traumatic brain injury in male rats: a behavioral, biochemical, and histological study
Our results demonstrate that CTX administration at doses of 100 and 200 mg/kg significantly improved neurological and motor function, reduced cerebral edema, enhanced blood-brain barrier integrity, and favorably modulated the post-traumatic inflammatory response. In contrast, the 400 mg/kg dose conferred no additional benefit.
Authors
- Morteza Biabani (ORCID: https://orcid.org/0000-0002-4806-0286)
- Ali Siahposht-Khachaki (ORCID: https://orcid.org/0000-0001-7505-3148)
- Davood Farzin (ORCID: https://orcid.org/0000-0002-9062-7610)
- Erfan Ghadirzadeh (ORCID: https://orcid.org/0000-0002-3903-0464)
- Tohid Emami Meybodi (ORCID: https://orcid.org/0000-0002-3652-846X)
- Fereshteh Talebpour Amiri (ORCID: https://orcid.org/0000-0002-4236-7439)
- Asal Safarbalou
- A R Monsef Esfahani
- Mobina Gheibi
- Ghazal Taghipour
Institutions
- Iran University of Medical Sciences (IR)
- University of Mazandaran (IR)
- Shahid Beheshti University of Medical Sciences (IR)
- Mazandaran University of Medical Sciences (IR)
Publication Details
- Journal
- Annals of Medicine and Surgery
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1097/ms9.0000000000004376
- Citations
- 1
- Primary Topic
- Traumatic Brain Injury and Neurovascular Disturbances
- Type
- article
- Field-Weighted Citation Impact
- 1.39